Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial

Wei-Jie Guan1, Chun-Hua Wei, Ai-Lan Chen, Xiao-Cong Sun, Guang-Yun Guo, Xu Zou,
Jin-Dong Shi, Pei-Zhen Lai, Ze-Guang Zheng, Nan-Shan Zhong

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China; 2Department of Respiratory Medicine, Weifang Wei’en Hospital, Weifang, China; 3Department of Respiratory Medicine, Wuhan Hanyang Hospital, Wuhan, China; 4Department of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China; 5Department of Respiratory and Critical Care Medicine, Wuhan Hankou Hospital, Wuhan, China; 6Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China; 7Intensive Care Unit, Shishou Hospital of Traditional Chinese Medicine, Shishou, China; 8Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China; 9Department of Respiratory and Critical Care Medicine, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China; 10Department of Infectious Diseases, Leishenshan Hospital, Wuhan, China; 11Department of Respiratory and Critical Care Medicine, Shanghai Fifth People’s Hospital, Shanghai, China; 12Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei #These authors contributed equally to this work.

Correspondence to: Nan-Shan Zhong. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, China.

Email: [email protected].

Submitted May 20, 2020. Accepted for publication Jun 15, 2020. doi: 10.21037/jtd-2020-057 View this article at: http://dx.doi.org/10.21037/jtd-2020-057