Complex treatment of ischemical and gangrenous form of diabetic foot patients
Dissertation on gaining of scientific degree of candidate of medical sciences in speciality 14.01.03
– Surgery – Vinnytsya National Pirogov Memorial Medical University, Ukrainian Ministry of Public Health. – Vinnytsya, 2007.
Dissertation is devoted to the decision of actual scientific task in industry of surgery to the improvement of results of medical treatment of patients with the ischemic-gangrenous form of syndrome of foot of diabetic on the basis of application of regional prolonged endarterial ozonotherapy and local ozonization of the staggered area.
By electronic-microscopic researches the role of allotropic form of oxygen is set as a stimulant factor of functional activity of macrophage. Stimulation of functional activity of macrophage under act of ozone, and also presence of destructive changes in these cages without the necrotic damages can be explained by the inclusion of mechanism of apoptosis, as a positive factor in adjusting of local homeostasis on completion of inflammatory phase of wound process.
Application of regional prolonged endarterial ozonotherapy and local ozonization of hearth of defeat in complex medical treatment of patients with the ischemic-gangrenous form of diabetic foot syndrome is instrumental in the reliable shortening of terms of healing of wounds and to decrease the quantity of “high amputations” from 8,6 to 3,8 %.