How much does ozone therapy need a real biochemical control system? The oxidative stress importance and assesmentPosted by: Lubov Pavlova in Articles
Ozone Research Center, National Center for Scientific Research,
POB.6880, Havana, Cuba.
Ozone therapy is not officially allowed in many countries, but medical private services are using this therapy all around the world. However, appropriate control systems to assess the benefits and risks of systemic ozone therapy are not always used and in such cases the treatment is based on anecdotal reports. Oxidative stress phenomenon is becoming as a highlighted biological process for ozone therapy because is deeply involved in its mechanism of action, and by the contrary ozone therapy is an efficient regulator of the oxidative stress processes. In terms of therapeutic effects it is convenient to know the metabolic status of the organism to face new oxidative challenges before and during ozone therapy applications. Oxidative stress is also important because it is involved as a cause or effect of many diseases. Since 1990 decade there is the necessity of developing reliable systems for measuring the oxidative stress that a human is undergoing. In this sense we have proposed a system for oxidative stress diagnosis which can serve as a control system for systemic ozone therapy applications. The system is based on the blood measurement of 8 biomarkers (GSH, GPx, GST, SOD, CAT, DC, SRATB and HPT) and the interpretation of these values by an algorithm developed in a computer program yielding 4 new indices (total antioxidant activity, total prooxidant activity, redox index and grade of oxidative stress). The system shows the patient redox status and estimation of the oxidative stress level, having these information??ôs relevant?† implications on the dosage and therapeutic effectiveness of ozone therapy.